Synthesis and anti-active oxygen properties of water-soluble metal porphyrins.
- Author:
Qing FENG
1
;
Li LIU
;
Feng LUO
;
Di-na SUN
;
Zao-ying LI
;
Yue-ning ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cobalt; Copper; Free Radical Scavengers; chemical synthesis; pharmacology; Hydrogen Peroxide; metabolism; Hydroxyl Radical; metabolism; In Vitro Techniques; Lipid Peroxidation; drug effects; Liver; metabolism; Malondialdehyde; metabolism; Manganese; Metalloporphyrins; chemical synthesis; pharmacology; Mice; Reactive Oxygen Species; metabolism; Zinc
- From: Acta Pharmaceutica Sinica 2004;39(9):711-715
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo synthesize four water-soluble metal porphyrins [5, 10, 15, 20-tetra[4-(4'-pyridine-1) butyloxy phenyl] metalloporphyrins bromide, metal = Zn (I), Cu (II), Mn (III) and Co (IV)] as analogous enzyme having two anti-active oxygen functions.
METHODSThe first function, scavenging O2-, has been proved by using riboflavine-methionine photoreduction methods. The second function, scavenging H2O2, has been demonstrated by using the oxidating Vit C. The third function, scavenging HO*, has been demonstrated by using Fenton reaction. The complexes were measured by the mice liver homogenate technique of mice.
RESULTSFour model compounds could scavenge O2- in the concentration range of 1.0 x 10(-5) - 1.0 x 10(-6) mol x L(-1), decompose H2O2 in the concentration of 1.5 x 10(-6) - 1.0 x 10(-6) mol x L(-1), scavenge HO* in the concentration of 2.0 x 10(-8) - 1.0 x 10(-8) mol x L(-1). All showed that they had obvious action of decreasing the lipid peroxidation in the concentration of 1.0 x 10(-7) mol x L(-1).
CONCLUSIONAll above-mentioned complexes were considered to be qualified analogous enzymes of anti-active oxygen.
