Electrochemical behavior of daunorubicin at Co/GC ion implantation modified electrode and the application of the electrode.
- Author:
Jing WANG
1
;
Jing-bo HU
;
Qi-long LI
Author Information
- Publication Type:Journal Article
- MeSH: Antibiotics, Antineoplastic; analysis; chemistry; Carbon; Cobalt; Daunorubicin; analysis; chemistry; Electrochemistry; Electrodes; Hydrogen-Ion Concentration
- From: Acta Pharmaceutica Sinica 2004;39(9):730-733
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo study the electrochemical behavior of daunorubicin at Co/GC ion implantation modified electrode.
METHODSWith Co/GC ion implantation modified electrode as working electrode, daunorubicin was determined by voltammetry in 0.05 mol x L(-1) Na2HPO4-KH2PO4 (pH 6.82) solution.
RESULTSA sensitive reductive peak of daunorubicin was obtained by linear sweep voltammetry. The peak potential was -0.60 V (vs SCE). The peak current was proportional to the concentration of daunorubicin over the range of 2.84 x 10(-8) - 1.42 x 10(-6) mol x L(-1) and 1.42 x 10(-6) - 1.28 x 10(-5) mol x L(-1) with the detection limit of 1.42 x 10(-8) mol x L(-1). The reduction wave was applied to the determination of daunorubicin. The electrochemical behavior and reaction mechanism were studied by linear sweep and cyclic voltammetry.
CONCLUSIONThe reduction process was quasi-reversible with adsorption characteristics.
