Effects of glucagon on islet beta cell function in patients with diabetes mellitus.
- Author:
Tong WANG
1
;
Xin-Hua XIAO
;
Wen-Hui LI
;
Heng WANG
;
Qi SUN
;
Tao YUAN
;
Guo-Hua YANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; C-Peptide; blood; Diabetes Mellitus, Type 1; drug therapy; Diabetes Mellitus, Type 2; drug therapy; Female; Glucagon; pharmacology; therapeutic use; Glycated Hemoglobin A; metabolism; Humans; Insulin; therapeutic use; Islets of Langerhans; drug effects; metabolism; Male; Middle Aged
- From: Chinese Medical Sciences Journal 2008;23(2):117-120
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo evaluate islet beta cell response to intravenous glucagon (a non-glucose secretagogue) stimulation in diabetes mellitus.
METHODSNineteen patients with type 1 diabetes (T1D) and 131 patients with type 2 diabetes (T2D) were recruited in this study. T2D patients were divided into two groups according to therapy: 36 cases treated with insulin and 95 cases treated with diet or oral therapy. The serum C-peptide levels were determined at fasting and six minutes after intravenous injection of 1 mg of glucagon.
RESULTSBoth fasting and 6-minute post-glucagon-stimulated C-peptide levels in T1D patients were significantly lower than those of T2D patients (0.76 +/- 0.36 ng/mL vs. 1.81 +/- 0.78 ng/mL, P < 0.05; 0.88 +/- 0.42 ng/mL vs. 3.68 +/- 0.98 ng/mL, P < 0.05). In T1D patients, the C-peptide level after injection of glucagon was similar to the fasting level. In T2D, patients treated with diet or oral drug had a significantly greater fasting and stimulated C-peptide level than those patients received insulin therapy (2.45 +/- 0.93 ng/mL vs. 1.61 +/- 0.68 ng/mL, P < 0.05; 5.26 +/- 1.24 ng/mL vs. 2.15 +/- 0.76 ng/mL, P < 0.05). The serum C-peptide level after glucagon stimulation was positively correlated with C-peptide levels at fasting in all three groups (r = 0.76, P < 0.05).
CONCLUSIONSThe 6-minute glucagon test is valuable in assessing the function of islet beta cell in patients with diabetes mellitus. It is helpful for diagnosis and treatment of diabetes mellitus.