Application of whole body diffusion weighted MR imaging for diagnosis and staging of malignant lymphoma.
- Author:
Shuo LI
1
;
Hua-Dan XUE
;
Jian LI
;
Fei SUN
;
Bo JIANG
;
Dong LIU
;
Hong-Yi SUN
;
Zheng-Yu JIN
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Diffusion Magnetic Resonance Imaging; methods; Female; Humans; Lymph Nodes; pathology; Lymphoma; diagnosis; pathology; Male; Middle Aged; Neoplasm Staging; methods; ROC Curve; Whole Body Imaging; methods; Young Adult
- From: Chinese Medical Sciences Journal 2008;23(3):138-144
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo evaluate the clinical impact of whole body diffusion weighted imaging (WB-DWI) on diagnosis and staging of malignant lymphoma.
METHODSThirty-one patients with suspected lymphadenopathy were enrolled. WB-DWI was performed by using short TI inversion recovery echo-planar imaging sequence with free breathing and built-in body coil. Axial T2-weighted imaging images of the same location were used as reference. The results of WB-DWI were compared with pathological results and other imaging modalities. The mean apparent diffusion coefficient (ADC) values of different kinds of lymph nodes were compared.
RESULTSWB-DWI was positive in all 18 cases with lymphoma, 5 cases with metastatic lymph nodes and 4 of 8 cases with benign lymphadenopathy. The mean ADC value of lymphomatous, metastatic and benign lymph nodes was (0.87 +/- 0.17) x 10(-3), (0.98 +/- 0.09) x 10(-3) and (1.20 +/- 0.10) x 10(-3) mm2/s. There was significant difference in ADC value between benign lymph nodes and other two groups (P < 0.01). The sensitivity, specificity and accuracy of WB-DWI in diagnosis of lymphoma were 100% (18/18), 30.8% (4/13) and 71.0% (22/31). When an ADC value of 1.08 x 10(-3) mm2/s was used as the threshold value for differentiating malignant from benign lymph nodes, the best results were obtained with sensitivity of 87.8% and specificity of 91.3%. Sixteen of eighteen cases (88.9%) of lymphoma were accurately staged in accordance with clinical staging.
CONCLUSIONSWB-DWI is a sensitive, but less specific technique for diagnosis of lymphoma. It is difficult to differentiate lymphomatous from metastatic lymph nodes using WB-DWI. However, it is a valuable imaging modality for staging of patients with malignant lymphoma.