Research progress in cytoplasmic PML gene functions.
10.7534/j.issn.1009-2137.2014.03.053
- Author:
Xiao-Hong XU
1
;
Yun-Yan SUN
1
;
Xue-Mei ZHANG
2
Author Information
1. Department of Hematology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China.
2. Department of Hematology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China. E-mail:zxm8955@sohu.com.
- Publication Type:Journal Article
- MeSH:
Cytoplasm;
genetics;
Humans;
Leukemia, Promyelocytic, Acute;
genetics;
Nuclear Proteins;
genetics;
Promyelocytic Leukemia Protein;
Transcription Factors;
genetics;
Tumor Suppressor Proteins;
genetics
- From:
Journal of Experimental Hematology
2014;22(3):857-860
- CountryChina
- Language:Chinese
-
Abstract:
The promyelocytic leukemia (PML) was originally identified and named as acute promyelocytic leukaemia (APL) . The PML, encoded by PML gene, locates in the nuclear body (NB) and shuttles in the cell nucleus-cytoplasm, so that PML completes many regulation functions. There are many research on the function of nuclear PML, but in recent years the foreign data indicate that cytoplasmic PML gene plays an important role in hematologic malignancies and solid tumors. In this article, the biological functions of PML gene in cytoplasm are reviewed.
