Expression of G-CSFR IV isoform in adult acute myeloid leukemia and its clinical significance.
10.7534/j.issn.1009-2137.2014.04.004
- Author:
Yong WU
1
;
Ying-Ying CHEN
1
;
Yuan-Zhong CHEN
2
Author Information
1. Fujian Institute of Hematology, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian Province, China.
2. Fujian Institute of Hematology, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian Province, China. E-mail: chenyz@mail.fjmu.edu.cn.
- Publication Type:Journal Article
- MeSH:
Case-Control Studies;
Hematopoietic Stem Cells;
metabolism;
Humans;
Leukemia, Myeloid, Acute;
metabolism;
Protein Isoforms;
metabolism;
Receptors, Granulocyte Colony-Stimulating Factor;
metabolism
- From:
Journal of Experimental Hematology
2014;22(4):899-902
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to investigate the expression of granulocyte colony-stimulating factor receptor IV(G-CSFR IV) in adult acute leukemia patients and its clinical significance. The bone marrow hematopoietic stem cells from healthy persons were used as controls. The real-time RT-PCR was used to determine the expression level of G-CSFR I-IV in 99 AML, 34 ALL patients and 19 healthy persons. The results showed that the relative expression level of G-CSFR IV/G-CSFR I in AML patients was obviously elevated, as compared with that in ALL patients and controls, while the relative expression level of G-CSFR IV/G-CSFR I in ALL patients showed no statistical difference from controls. The analysis of clinical features and chemotherapeutic efficacy demonstrated that the clinical remission rate in patients with high expression of G-CSFR IV/G-CSFR I was lower than that in patients with low expression. The relative expression level of G-CSFR IV/G-CSFR I was not related with risk stratification from sex, age, blast ratio, FAB typing, chromosome and fusion gene. It is concluded that the abnormal high expression of G-CSFR IV relates with poor prognosis of AML.
