Clinical analysis of 202 cases of extranodal NK/T-cell lymphoma.
10.7534/j.issn.1009-2137.2014.04.021
- Author:
Chao MA
1
;
Jian BO
1
;
Ting LIU
1
;
Sheng YAO
1
;
Yu ZHAO
2
Author Information
1. Department of Hematology, Chinese PLA's Gereml Hospital, Beijing 100853, China.
2. Department of Hematology, Chinese PLA's Gereml Hospital, Beijing 100853, China. E-mail: zhaoyu301@126.com.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Aged, 80 and over;
Child;
Disease-Free Survival;
Female;
Humans;
Lymphoma, Extranodal NK-T-Cell;
diagnosis;
therapy;
Male;
Middle Aged;
Multivariate Analysis;
Prognosis;
Proto-Oncogene Proteins c-bcl-2;
metabolism;
Retrospective Studies;
Survival Rate;
Treatment Outcome;
Young Adult
- From:
Journal of Experimental Hematology
2014;22(4):999-1004
- CountryChina
- Language:Chinese
-
Abstract:
This study was purposed to explore the therapeutic strategy and factors influencing prognosis through the analysis of clinical characteristics, genetic aberrations, treatment and prognosis of the patients with extranodal NK/T cell lymphoma (ENKTL). A total of 202 patients with ENKL from 2005-2013 were analyzed retrospectively in term of Ann Arbor stage, B symptoms, lactate dehydrogenase (LDH), international prognostic index (IPI), β2-microglobulin and the expression of MYC,HXO11,BCL-2. The survival was analyzed using Kaplan-Meier method, and the COX regression model was employed for multivariate analysis. The results showed that the 5 year overall survival (OS) rate and event-free survival (EFS) rate were 61.9% and 53.9% respectively; chemoradiotherapy was apparently better than chemotherapy alone for OS and EFS; OS and EFS of the patients with BCL-2 expression were apparently better than patients without BCL-2 expression; multivariant analysis by COX regression showed that Ann Arbor stage and BCL-2 expression were independent prognostic factors for EFS/OS. It is concluded that chemoradiotherapy is better than chemotherapy alone for treatment of ENKL. Ann Arbor stage and BCL-2 expression are independent prognostic factors.
