Structure and function of ADAMTS13 protease and its relation with diagnosis and treatment of TTP.
10.7534/j.issn.1009-2137.2014.04.052
- Author:
Qian WANG
1
;
Yue HAN
2
Author Information
1. Department of Hematology, The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis, Ministry of Health, Suzhou 215006, Jiangsu Province, China.
2. Department of Hematology, The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis, Ministry of Health, Suzhou 215006, Jiangsu Province, China. E-mail: hanyuesz@163.com.
- Publication Type:Journal Article
- MeSH:
ADAM Proteins;
metabolism;
ADAMTS13 Protein;
Humans;
Purpura, Thrombotic Thrombocytopenic;
diagnosis;
pathology;
therapy
- From:
Journal of Experimental Hematology
2014;22(4):1157-1161
- CountryChina
- Language:Chinese
-
Abstract:
ADAMTS13, a plasma metalloprotease, specifically cleaves von Willebrand factor (vWF). Severe deficiency of plasma ADAMTS13 activity results in thrombotic thrombocytopenic purpura (TTP). In this review, the structure and function of ADAMTS13 protease and its relationship with TTP are summarized.
