Linkage analysis of a region on chromosome 2 with essential hypertension in Chinese families.
- Author:
Dingliang ZHU
1
;
Wei HUANG
;
Houyi WANG
;
Momiao XIONG
;
Shaoli CHU
;
Li JIN
;
Guliang WANG
;
Xin HE
;
Wentao YUAN
;
Yuecheng QIAN
;
Guangsheng ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: Alleles; China; Chromosomes, Human, Pair 2; genetics; Family Health; Female; Gene Frequency; Genetic Linkage; Humans; Hypertension; genetics; Linkage Disequilibrium; Male; Microsatellite Repeats
- From: Chinese Medical Journal 2002;115(5):654-657
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo verify the linkage of the candidate regions identified in a previous study (markers D2S168, D2S151, D2S142 on chromosome 2) with hypertension in Chinese families.
METHODSA genetic linkage study focused on chromosome 2 was performed on 240 Chinese families containing 856 patients with essential hypertension. A total of 1080 individuals were genotyped using 9 highly polymorphic microsatellite markers around the candidate regions on chromosome 2 with an average spacing of 5 cM. Non-parametric linkage (NPL), parametric linkage analysis and transmission-disequilibrium test (TDT) with the GENEHUNTER software were used to assess evidence for linkage.
RESULTSLinkage of a region on chromosome 2 around D2S151 and D2S142 with hypertension was confirmed by different statistical methods (NPL, LOD score and TDT). However, the linkage of D2S168 could not be replicated in this extension study.
CONCLUSIONSThe data suggest that a region on chromosome 2 at or near the loci of D2S142 and D2S151 may harbor genes responsible for the development of essential hypertension in Chinese.
