Expressions of vascular endothelial growth factor and cyclooxygenase-2 in patients with multiple myeloma and its significance.
- Author:
Hong-Yu BAO
1
;
Ming-Qin ZHU
;
Miao JIANG
;
Ning-Zheng DONG
;
Chang-Geng RUAN
Author Information
1. Suzhou University, Jiangsu Institute of Hematology, Suzhou 215007, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Case-Control Studies;
Cyclooxygenase 2;
blood;
Humans;
Middle Aged;
Multiple Myeloma;
blood;
Vascular Endothelial Growth Factor A;
blood
- From:
Journal of Experimental Hematology
2009;17(1):99-101
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to investigate the expressions of vascular endothelial growth factor (VEGF) and cyclooxygenase-2 (COX-2) in patients with multiple myeloma (MM) and its clinical significance. Expression of VEGF was detected by enzyme linked immunosorbent assay (ELISA) and the level of COX-2 was detected by Western blot. The results showed that the serum VEGF level of multiple myeloma patients (365.34 +/- 65.63 pg/ml) was higher than that in the normal persons (122.52 +/- 39.29 pg/ml) (p < 0.05); the serum VEGF level of patients at advanced stage (395.07 +/- 54.90) pg/ml was higher than those at stable stage (300.33 +/- 44.22) pg/ml (p < 0.05). The serum Cox-2 positive rate in the patients (31%) was higher than that in normal persons (0%) (p < 0.01); the serum Cox-2 positive rate in the patients at advanced stage (50%) was higher than those at stable stage (21%) (p < 0.01). It is concluded that VEGF and COX-2 may play an important role in the pathogenesis and development of multiple myeloma, they can be used to evaluate the status of patients with MM.
