Correlation between gene polymorphism of endothelial protein C receptor and cerebral infarction in Chinese Han population of Hubei province.
- Author:
Xiao-Bei WANG
1
;
Li-Hua HU
Author Information
1. Department of Clinical Laboratory Examination, Huazhong University of Science and Techno-logy, Wuhan 430022, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Antigens, CD;
genetics;
Asian Continental Ancestry Group;
genetics;
Case-Control Studies;
Cerebral Infarction;
genetics;
Endothelial Protein C Receptor;
Female;
Gene Frequency;
Genotype;
Humans;
Male;
Middle Aged;
Polymorphism, Genetic;
Receptors, Cell Surface;
genetics
- From:
Journal of Experimental Hematology
2009;17(1):203-205
- CountryChina
- Language:Chinese
-
Abstract:
In order to explore the distribution frequency of endothelial protein C receptor (EPCR) gene A6936G variant and to study the correlation between this mutation and cerebral infarction in Chinese Han population of Hubei province district. The genotype and allele frequencies of EPCR A6936G were identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 380 cerebral infarction patients and 380 healthy Chinese Han persons. The results indicated that the frequencies of A/A, A/G and G/G genotypes in cerebral infarction group were 77.1%, 22.1% and 0.8% respectively. While the frequencies of A/A and A/G genotypes in control group were 88.2% and 11.8%, and without G/G genotype. It is concluded that A6936G polymorphism of EPCR can be detected in Chinese Han population of Hubei province district, which may be correlated with the increasing risk of thrombosis in cerebral infarction patients.
