Progress of study on the roles of matrix metalloproteinases in the pathogenesis of hematologic malignancies -- review.
- Author:
Xi-Shan ZHU
1
;
Bin ZHANG
;
Ruei LU
;
Xiao-Wei DOU
;
Chun-Hua ZHAO
Author Information
1. Peking Union Medical College, Chinese Academy of Medical Sciences, China.
- Publication Type:Journal Article
- MeSH:
Hematologic Neoplasms;
pathology;
Humans;
Matrix Metalloproteinases
- From:
Journal of Experimental Hematology
2009;17(1):229-233
- CountryChina
- Language:Chinese
-
Abstract:
Matrix metalloproteinases (MMPs) have the ability to degrade extracellular matrix components. They abnormally express in a variety of solid tumors and hematologic malignancies, and play an important role in tumor invasion and metastasis through extracellular matrix degradation, which closely relates with the progression and prognosis of the malignant disease. This article reviews progress of study on the mechanism of MMP underlying the pathogenesis of hematologic malignancies, including structure of MMP, regulation mechanism of MMP and its relation with proliferation and differentiation of hematopoietic stem cells (HSC), angiogenesis and tumor immunology and so on.
