Co-infection of hepatitis C virus among newly diagnosed HIV-infected adults in Taizhou prefecture of Zhejiang province, China
10.3760/cma.j.issn.0254-6450.2015.08.020
- VernacularTitle:浙江省台州市新报告成年HIV感染者中HCV合并感染研究
- Author:
Lin ZHOU
1
;
Qionghai WU
;
Weiwei SHEN
;
Meiyang GAO
;
Yingying DING
;
Haijiang LIN
;
Na HE
Author Information
1. 复旦大学公共卫生学院公共卫生安全教育部重点实验室
- Keywords:
HIV;
Hepatitis C virus;
Coinfection;
Viral load
- From:
Chinese Journal of Epidemiology
2015;36(8):862-866
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the prevalence and correlates of hepatitis C virus (HCV) co-infection as well as plasma HCV viral load among newly diagnosed HIV-infected adults during 2009-2012 in Taizhou prefecture of Zhejiang province,China.Methods Five hundred and seventy-two adults who were newly diagnosed as HIV-infection were screened for anti-HCV immunoglobulin G (IgG).Plasma HCV RNA was quantified if positive for HCV IgG.Results Forty-two (7.3％) out of the 572 HIV-infected adults were tested positive for HCV IgG.HCV infection was more likely to occur among participants who were infected with HIV through blood transmission (OR=49.46,95％CI:13.71-178.48).Otherwise,HCV infection was less likely to occur among participants who were under 46-86 years of age (OR=0.12,95％CI:0.02-0.58),those with mode of homosexual transmission of HIV (OR=0.11,95％ C I:0.01-0.86),with education of high school or above (OR=0.13,95％ CI:0.02-0.78).Thirty-three (78.6％) of the total 42 HIV-HCV patients with coinfection had detectable plasma HCV RNA,whereas 9 (21.4％) had undetectable plasma HCV RNA (i.e.,lower than 5.0 × 102 IU/ml) or known as relative HCV viral suppression.No significant associations were noticed on factors as:HCV viral suppression and demographics,HIV transmission route and CD4 + T-cell counts according to univariate regression analyses.Conclusion Prevalence of HCV co-infection was relatively high among newly diagnosed HIV-infected adults in this study area.Majority of the HIV-HCV coinfected patients had detectable plasma HCV RNA,of which the long term impact on disease progression deserves called for further research.
