A dose-response analysis on the association of gestational weight gain rate and the normal term neonate birth weight
10.3760/cma.j.issn.0254-6450.2015.08.024
- VernacularTitle:孕期体重变化率与足月产新生儿体重关联剂量反应关系的研究
- Author:
Yuanyuan MAO
1
,
2
;
Wenbin HU
;
Qin LIU
;
Li LIU
;
Yuanming LI
;
Yueping SHEN
Author Information
1. 215300 江苏省昆山市第一人民医院妇产科
2. 江苏大学附属昆山医院
- Keywords:
Gestational weight gain rate;
Birth weight;
Restricted cubic spline
- From:
Chinese Journal of Epidemiology
2015;36(8):879-883
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the dose-response relationship between gestational weight gain rate and the neonate birth weight.Methods A total of 18 868 women with singleton gestations who delivered between January 2006 and December 2013 were included in this study.Maternal and neonate details of these women were drawn from the Perinatal Monitoring System database.Gestational weight gain rate was defined as the total weight gain during the last and first prenatal care visits divided by the interval weeks.Both Multiple logistic regression analysis and restricted cubic spline methods were performed.Confounding factors included maternal age,education,pre-pregnancy body mass index (BMI),state of residence,parity,gestational weeks of prenatal care entry,and sex of the neonate.Results The adjusted odds ratio for macrosomia was associated with gestational weight gain rate in lower pre-pregnancy BMI (OR=3.15,95％CI:1.40-7.07),normal (OR=3.64,95％CI:2.84-4.66) or overweight (OR=2.37,95％CI:1.71-3.27).The odds ratios of low birth weight appeared a decrease in those women with lower pre-pregnancy BMI (OR=0.28,95％CI:0.13-0.61) while the normal weight (OR=0.37,95％CI:0.22-0.64) group with gestational weight gain,the rate showed an increase.Association of gestational weight gain rate for macrosomia was found a S-curve in those term delivery women (non-linearity test P＜0.000 1).However,L-curve was observed for low birth weight and gestational weight gain rate in term births (non-linearity test P＜0.000 1).Conclusion A S-curve was seen between gestational weight gain rate and term delivered macrosomia while L-curve was observed among term delivered low birth weight neonates.
