Prevalence and metabolic risk factors of nonalcoholic fatty liver disease in a middle-aged and elderly population in Guangzhou
10.3760/cma.j.issn.0254-6450.2015.09.011
- VernacularTitle:广州市中老年人非酒精性脂肪肝患病率及代谢相关因素分析
- Author:
Yi CAO
1
,
2
;
Cheng WANG
;
Wenqi SHI
;
Yingying ZHU
;
Gengdong CHEN
;
Yuming CHEN
Author Information
1. 510080 广州,中山大学公共卫生学院医学统计与流行病学系
2. 广州中山大学第一附属医院病案管理科
- Keywords:
Nonalcoholic fatty liver disease;
Prevalence;
Metabolic factor
- From:
Chinese Journal of Epidemiology
2015;36(9):958-961
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prevalence of nonalcoholic fatty liver disease (NAFLD) and understand the relationship between NAFLD and metabolic risk factors in middle-aged and elderly adults.Methods This cross-sectional study recruited 2 935 subjects in Guangzhou,Guangdong province.Face-to-face interviews and laboratory analyses were conducted to collect general information and other covariates.Analysis of covariance and logistic regression analysis were performed to investigate the relationship between metabolic factors and the prevalence of NAFLD.NAFLD was diagnosed based on standard criteria recommend by the Fatty Liver Disease and Alcoholic Liver Disease Branch of Chinese Hepatology Society,and the degree of steatosis was assessed (mild,moderate or severe).Results Compared with normal subjects,those with NAFLD had higher levels of WC,BMI,FPG,TG,SBP,DBP and greater prevalence of metabolic syndrome,but lower levels of physical activity and HDL-C.After adjusted for covariates,the OR for each standard deviation change was 2.70(95％CI:2.45-2.98) for WC,1.47(95％ CI:1.35-1.59) for SBP,1.48 (95％CI:1.37-1.60) for DBP,1.88 (95％CI:1.66-2.12) for TG,1.25 (95％ CI:1.15-1.36) for FPG and 0.51 (95％CI:0.47-0.56) for HDL-C (all P＜0.001).Higher levels of WC,BMI,TG,SBP,DBP and FPG were significantly related with the increase in degree of NAFLD (P-trend＜0.001).Conclusion There is a relatively high prevalence of NAFLD in middle-aged and elderly adults in China.NAFLD is closely related with the different forms of metabolic syndrome,and WC is the leading risk factor for NAFLD.
