CTCF as a multifunctional protein in genome regulation and gene expression.
- Author:
Somi KIM
1
;
Nam Kyung YU
;
Bong Kiun KAANG
Author Information
- Publication Type:Research Support, Non-U.S. Gov't ; Review
- MeSH: Animals; Cell Cycle Proteins/metabolism; Chromosomal Proteins, Non-Histone/metabolism; *Gene Expression Regulation; Genome; Humans; Protein Binding; Protein Interaction Maps; Repressor Proteins/analysis/*metabolism
- From:Experimental & Molecular Medicine 2015;47(6):e166-
- CountryRepublic of Korea
- Language:English
- Abstract: CCCTC-binding factor (CTCF) is a highly conserved zinc finger protein and is best known as a transcription factor. It can function as a transcriptional activator, a repressor or an insulator protein, blocking the communication between enhancers and promoters. CTCF can also recruit other transcription factors while bound to chromatin domain boundaries. The three-dimensional organization of the eukaryotic genome dictates its function, and CTCF serves as one of the core architectural proteins that help establish this organization. The mapping of CTCF-binding sites in diverse species has revealed that the genome is covered with CTCF-binding sites. Here we briefly describe the diverse roles of CTCF that contribute to genome organization and gene expression.
