Mitochondrial Energy Metabolism and Thyroid Cancers.
10.3803/EnM.2015.30.2.117
- Author:
Junguee LEE
1
;
Joon Young CHANG
;
Yea Eun KANG
;
Shinae YI
;
Min Hee LEE
;
Kyong Hye JOUNG
;
Kun Soon KIM
;
Minho SHONG
Author Information
1. Department of Pathology, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Daejeon, Korea.
- Publication Type:Review
- Keywords:
Thyroid neoplasms;
Mitochondria;
Energy metabolism
- MeSH:
Carcinogenesis;
Carcinoma;
Disease Progression;
Energy Metabolism*;
Iodine;
Mitochondria;
Oncogenes;
Phenotype;
Thyroid Gland*;
Thyroid Neoplasms;
Biomarkers
- From:Endocrinology and Metabolism
2015;30(2):117-123
- CountryRepublic of Korea
- Language:English
-
Abstract:
Primary thyroid cancers including papillary, follicular, poorly differentiated, and anaplastic carcinomas show substantial differences in biological and clinical behaviors. Even in the same pathological type, there is wide variability in the clinical course of disease progression. The molecular carcinogenesis of thyroid cancer has advanced tremendously in the last decade. However, specific inhibition of oncogenic pathways did not provide a significant survival benefit in advanced progressive thyroid cancer that is resistant to radioactive iodine therapy. Accumulating evidence clearly shows that cellular energy metabolism, which is controlled by oncogenes and other tumor-related factors, is a critical factor determining the clinical phenotypes of cancer. However, the role and nature of energy metabolism in thyroid cancer remain unclear. In this article, we discuss the role of cellular energy metabolism, particularly mitochondrial energy metabolism, in thyroid cancer. Determining the molecular nature of metabolic remodeling in thyroid cancer may provide new biomarkers and therapeutic targets that may be useful in the management of refractory thyroid cancers.
