Association between retinol-binding protein 4 and coronary artery disease in Chinese: a Meta-analysis
10.3760/cma.j.issn.0254-6450.2015.09.022
- VernacularTitle:中国人视黄醇结合蛋白4水平与冠心病关系的Meta分析
- Author:
Xiaowen HOU
1
;
Guangxiao LI
;
Qiongrui ZHAO
;
Xin CHEN
;
Chong WANG
;
Jingpu SHI
Author Information
1. 中国医科大学附属第一医院临床流行病学与循证医学教研室 循证医学教育部网上合作研究中心 中国医科大学分中心
- Keywords:
Coronary artery disease;
Retinol-binding protein 4;
Case-control study;
Meta-analysis
- From:
Chinese Journal of Epidemiology
2015;36(9):1010-1014
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the association between retinol-binding protein 4 (RBP4) and coronary artery disease (CAD) in Chinese.Methods A document retrieval was conducted by using retrieval systems,such as PubMed,Web of Science,Cochrane Library,Chinese National Knowledge Infrastructure (CNKI),CBM,VIP and WanFang Database,to collect the published papers of case-control studies on association between RBP4 and CAD in Chinese up to February,2015.Data collection and quality assessment were completed by two authors respectively.All the analyses were conducted with software RevMan 5.2.Results A total of 10 qualified studies were included in our meta-analysis.The pooled analysis showed that RBP4 might be associated with CAD in Chinese [WMD=7.17 (95％CI:3.56-10.78) μg/ml,P＜0.05].Clinical subtype specific subgroup analysis showed RBP4 might be also associated with both stable angina pectoris [WMD=4.81 (95％ CI:1.25-8.37) μg/ml,P＜0.05] and acute myocardial infarction [WMD=13.96(95％CI:6.12-21.80) μg/ml,P＜0.05].Age specific subgroup analysis showed the significant association between RBP4 and CAD was only found in patients aged ≤65 years [WMD=7.26(95％CI:2.73-11.79)μg/ml,P＜0.05].Sensitivity and publication bias analyses indicated that our results were stable and reliable.Conclusion The meta-analysis suggests that RBP4 might be associated with CAD in Chinese.
