Co-expression of immunoglobulin light chain kappa and lambda in gastric carcinoma cell.
- Author:
Shaobo YANG
1
;
Mengwei WANG
;
Weidi YOU
Author Information
- Publication Type:Journal Article
- MeSH: Gene Rearrangement, B-Lymphocyte, Light Chain; Humans; Immunoglobulin kappa-Chains; biosynthesis; genetics; Immunoglobulin lambda-Chains; biosynthesis; genetics; Immunohistochemistry; Stomach Neoplasms; immunology; metabolism
- From: Chinese Journal of Oncology 2002;24(5):465-466
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the expression of immunoglobulin light chain kappa and lambda (Igkappa and Iglambda) in gastric carcinoma cell and their co-expression.
METHODSIgkappa and Iglambda of 22 human gastric carcinoma specimens embedded in paraffin were monitored through immunohistochemical method-LSAB method.
RESULTSAmong 22 gastric carcinoma specimens, both Igkappa and Iglambda were positive in 17 (77.3%), only Igkappa was positive in 2 (9.1%), only Iglambda was positive in 1 (4.5%), both Igkappa and Iglambda negative in 2 (9.1%). The expression of Igkappa and Iglambda in human gastric carcinoma cell showed significant close correlation (chi(2) = 5.49, P < 0.05).
CONCLUSIONCo-expression of immunoglobulin light chain kappa and lambda in gastric carcinoma cell is common, which suggests that the activation mechanism of immunoglobulin gene in gastric carcinoma cell may be different from that in B-lymphocytes. Study on co-expression of immunoglobulin light chain kappa and lambda in gastric carcinoma is promising.
