Clinical Implications of Glucose Variability: Chronic Complications of Diabetes.
10.3803/EnM.2015.30.2.167
- Author:
Hye Seung JUNG
1
Author Information
1. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. junghs@snu.ac.kr
- Publication Type:Review
- Keywords:
Glucose variability;
Microvascular complications;
Macrovascular complications
- MeSH:
Coronary Artery Disease;
Diabetes Complications;
Glucose*;
Humans;
Oxidative Stress;
Risk Factors
- From:Endocrinology and Metabolism
2015;30(2):167-174
- CountryRepublic of Korea
- Language:English
-
Abstract:
Glucose variability has been identified as a potential risk factor for diabetic complications; oxidative stress is widely regarded as the mechanism by which glycemic variability induces diabetic complications. However, there remains no generally accepted gold standard for assessing glucose variability. Representative indices for measuring intraday variability include calculation of the standard deviation along with the mean amplitude of glycemic excursions (MAGE). MAGE is used to measure major intraday excursions and is easily measured using continuous glucose monitoring systems. Despite a lack of randomized controlled trials, recent clinical data suggest that long-term glycemic variability, as determined by variability in hemoglobin A1c, may contribute to the development of microvascular complications. Intraday glycemic variability is also suggested to accelerate coronary artery disease in high-risk patients.
