Clinical trial of lentaron for postmenopausal patients with advanced breast cancer.
- Author:
Xiaoqing LIU
1
;
Santai SONG
;
Zefei JIANG
;
Shikai WU
;
Jingxin YU
;
Tao WANG
Author Information
- Publication Type:Clinical Trial
- MeSH: Androstenedione; adverse effects; analogs & derivatives; therapeutic use; Antineoplastic Agents; adverse effects; therapeutic use; Breast Neoplasms; drug therapy; pathology; Disease Progression; Female; Humans; Neoplasm Metastasis; Neoplasm Staging; Postmenopause; Treatment Outcome
- From: Chinese Journal of Oncology 2002;24(5):511-513
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the efficacy and adverse effects of lentaron for postmenopausal patients with recurrent and metastatic breast cancer.
METHODSThirty-four patients with recurrent and metastatic breast cancer received 250 mg lentaron by intramuscular injection every 2 weeks for at least one month.
RESULTSIn 34 patients who were evaluable for efficacy and toxicity, the complete response rate (CR), partial response rate (PR), disease stabilization rate (SD) and progressive disease rate (PD) were 0%, 14.7%, 58.8% and 26.5%. The clinical benefit rate (CR + PR + SD >/= 6 months) was 50.0%. (17/34) with 12 patients (35.3%) having SD for at least 6 months. The response rates for bone, soft tissue and visceral metastasis were 28.6% (3/14), 13.6% (3/22) and 5.3% (1/19), respectively. There were no severe adverse effects in the treatment bylentaron.
CONCLUSIONLentaron is a well tolerated agent with reasonable efficacy but low toxicity for postmenopausal patients with recurrent and metastatic breast cancer.
