Assessment of nasopharyngeal carcinoma risk by EB virus antibody profile.
- Author:
Weimin CHENG
1
;
Guoxiong CHEN
;
Honglin CHEN
;
Ruixian LUO
;
Zibo WU
;
Yingsi LU
;
Bojian ZHENG
;
Mingfang JI
;
Jinsheng LIANG
;
Xintang CEN
;
Dekun WANG
;
Yongsheng ZONG
;
Wenhan WU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Viral; analysis; Enzyme-Linked Immunosorbent Assay; Epstein-Barr Virus Nuclear Antigens; analysis; Female; Herpesvirus 4, Human; isolation & purification; Humans; Male; Middle Aged; Nasopharyngeal Neoplasms; diagnosis; virology; Risk Factors
- From: Chinese Journal of Oncology 2002;24(6):561-563
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the risk of nasopharyngeal carcinoma (NPC) through EB virus antibody profile by enzyme linked immunosorbent assay (ELISA).
METHODSEBNA 1/IgA, EBNA 1/IgG and zta/IgG by ELISA and VCA/IgA by immmunoenzymatic method were detected in 121 NPC patients and 332 healthy subjects (HS) in the Pearl river estuary.
RESULTSThe sensitivity rates were 85%, 83% and 79% for EBNA 1/IgA, EBNA 1/IgG and zta/IgG, all three of which if combined was the highest 92%. The specificity rates were 86%, 86% and 80% for EBNA 1/IgA, EBNA 1/IgG and zta/IgG, all three of which if combined was also the highest 93%. According to the level of odds ratio, nasopharyngeal carcinoma risk could be divided into 3 groups: low, moderate and high-risk groups. 93% of HS had low risk of NPC with the odds ratio 0.0 to 0.3. 0.4% of HS had high risk of NPC with the odds ratio of 137.9%.
CONCLUSIONELISA is more objective than the traditional immunoenzymatic method in the detection and diagnosis of NPC. The combination of EBNA 1/IgA, EBNA 1/IgG and zta/IgG is able to evaluate the risk of NPC.
