The construction of two kinds of artificial bone and the comparison of their osteogenesis capability in vivo.
- Author:
Qi-qing ZHANG
1
;
Li-hai ZHANG
;
Ling-rong LIU
;
Yi LIANG
;
Bai-zhi REN
;
Fu-jun WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Biocompatible Materials; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; pharmacology; Bone Regeneration; Bone Substitutes; Chondroitin Sulfates; Collagen; Hydroxyapatites; Implants, Experimental; Osteoblasts; cytology; Osteogenesis; drug effects; Rats; Transforming Growth Factor beta
- From: Acta Academiae Medicinae Sinicae 2003;25(1):17-21
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo construct artificial bone with collagen-hydroxyapatite (HA) or collagen-HA-chondroitin sulfate (CS) as the scaffolds, and observe their biological properties.
METHODSThe artificial bones were constructed by attaching recombinant human bone morphogenetic protein 2 (rhBMP-2) on those scaffolds. And then they were embedded into muscles of rats. Every weekend those newly formed bones were taken from muscles for comparing the difference in osteogenetic capability of two kinds of artificial bone in vivo.
RESULTSBoth kinds of artificial bones could induce bone regeneration in muscle. The collagen-HA-CS artificial bone was superior to the collagen-HA artificial in bone-guided degree.
CONCLUSIONSThe CS could promote the form action of new bone and accelerate the bone healing.
