The study of biological properties of gliomas.
- Author:
Gang LI
1
;
Qing-lin ZHANG
;
Jie-zhen WANG
;
Fu-sheng LIU
;
Yong-sheng HU
;
Cheng-wei WANG
;
Xin-gang LI
;
Qi PANG
Author Information
1. Department of Neurosurgery, No. 2 Hospital of Shandong University, Jinan 250033, China.
- Publication Type:Journal Article
- MeSH:
Angiostatins;
pharmacology;
Animals;
Biological Therapy;
Brain Neoplasms;
secretion;
therapy;
Drug Resistance, Neoplasm;
Glioma;
secretion;
therapy;
Humans;
Interleukin-6;
genetics;
secretion;
RNA, Messenger;
genetics;
secretion;
Th1 Cells;
metabolism;
Th2 Cells;
metabolism
- From:
Acta Academiae Medicinae Sinicae
2003;25(1):88-92
- CountryChina
- Language:Chinese
-
Abstract:
In order to explore the new methods of biological treatment of human gliomas, this project is to study the biological properties of gliomas from four different aspects, the results show that there is a IL-6 autocrine loop in human gliomas and the growth of gliomas will be inhibited when the autocrine loop is broken. There is a magnificent predominant expression of Th2 cytokines in human gliomas and human glioma cells, the switching of Th2 to Th1 can inhibit the proliferation of glioma cells. The dosage of 100 micrograms/ml of erythromycin is the best of therapeutic effect. Angiostatin can not only inhibit the vascular endothelial growth, but also have the inhibitory role on the growth of glioma cells in vivo. The above studies have provided some new ideas and will be very helpful for the treatment of glioma patients.
