Non-diabetic renal disease in type II diabetes mellitus.
- Author:
Hang LI
1
;
Xue-wang LI
;
Qing-yuan HUANG
;
Wen-ling YE
;
Lin DUAN
;
Yan LI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Biopsy, Needle; Cohort Studies; Diabetes Mellitus, Type 2; complications; pathology; Female; Glomerulonephritis; complications; pathology; Glomerulonephritis, IGA; complications; pathology; Humans; Kidney; pathology; Male; Middle Aged; Retrospective Studies
- From: Acta Academiae Medicinae Sinicae 2003;25(1):101-104
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVESeveral studies have suggested that non-diabetic renal disease (NDRD) was common among non-insulin dependent diabetes mellitus (NIDDM) patients with renal involvement.
METHODSThe prevalence of NDRD among Chinese NIDDM population in PUMC hospital center was retrospectively studied. Renal biopsy specimens were evaluated with light-, immunofluorescence- and electron-microscopy. The cohort consisted of 33 NIDDM patients who received renal biopsy.
RESULTSPatients with both isolated diabetic nephropathy (DN, n = 7) and NDRD (n = 22) had comparable duration of DM, creatinine clearance, serum creatinine, albumin and 24 hours proteinuria, as well as incidences of retinopathy, neuropathy and hypertension. Significantly more patients with NDRD had haematuria (P = 0.030) or non-nephrotic proteinuria (P = 0.016). IgA nephropathy accounted for 40.9% of the NDRD identified.
CONCLUSIONSIn this study, haematuria and non-nephrotic proteinuria predicted the presence of NDRD among NIDDM patients complicated with renal disease. IgA nephropathy is the most frequent type of NDRD in Chinese.
