Hedgehog signaling pathway and osteoporosis.
- Author:
Ming LUO
;
Hong-Xing HUANG
;
Hong HUANG
;
Ze-Tian LI
;
Yuan-Yuan LAI
- Publication Type:Journal Article
- MeSH:
Cell Differentiation;
Core Binding Factor Alpha 1 Subunit;
genetics;
physiology;
Hedgehog Proteins;
physiology;
Humans;
Mesenchymal Stromal Cells;
cytology;
Osteoblasts;
cytology;
Osteoporosis;
drug therapy;
etiology;
Signal Transduction;
physiology;
Sp7 Transcription Factor;
Transcription Factors;
genetics;
physiology
- From:
China Journal of Orthopaedics and Traumatology
2014;27(2):169-172
- CountryChina
- Language:Chinese
-
Abstract:
Hedgehog signaling pathway is a conserved and important signaling pathway involved in proliferation and differentiation of many types of cells. Latest studies have found that Hedgehog signaling pathway may induce MSCs osteoblast differentiation by increasing the expression of the Runx2 and Osx and inhibit MSCs differentiate to adipocyte. Hedgehog signaling pathway may also promote osteoblast proliferation by regulating cyclin. This review summarizes the mechanism that Hedgehog signaling pathway regulates osteoblast differentiation and proliferation,and concludes that Hedgehog signaling pathway can regulate bone metabolism. It might provide new ideas for the treatment of osteoporosis.
