Progress on bone marrow mesenchymal stem cells transplantation for spinal cord injury.
- Author:
Li WANG
;
Qian WANG
;
Xiao-Ming ZHANG
- Publication Type:Journal Article
- MeSH:
Animals;
Bone Marrow Cells;
cytology;
Humans;
Mesenchymal Stem Cell Transplantation;
methods;
Mesenchymal Stromal Cells;
cytology;
Spinal Cord Injuries;
surgery
- From:
China Journal of Orthopaedics and Traumatology
2014;27(5):437-440
- CountryChina
- Language:Chinese
-
Abstract:
Bone marrow mesenchymal cells (BMSCs) are regarded as donor cells in cell transplantation therapies for spinal cord injury (SCI) for they have the ability of favourable proliferation and multi-directional differentiation, and are easily isolated and culturd and have less immunological reaction. It has been confirmed that subarachnoid space injection is the most ideal delivery technique of BMSCs. Bone marrow mesenchymal stem cells transplantation is safe and its reconditioning role is certain for SCI in early clinical application. The mechanism of BMSCs promoting functional recovery after SCI is probably concerned with vicarious function, nerve trophism, immunosuppression and promoting axonal regeneration by BMSCs.
