Correlation of Gemin 3 SNP in the microRNA Biosynthesis Pathway with Risk and Prognosis of Patients with Non-Hodgkin's Lymphoma.

Gui-min Zhao; Lan-ping Diao; Li-hong Liu; Xiao-lin WU; Zhe Gao; Yu-huan Gao

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Correlation of Gemin 3 SNP in the microRNA Biosynthesis Pathway with Risk and Prognosis of Patients with Non-Hodgkin's Lymphoma.

Author: Gui-Min ZHAO ¹ ; Lan-Ping DIAO ¹ ; Li-Hong LIU ¹ ; Xiao-Lin WU ¹ ; Zhe GAO ¹ ; Yu-Huan GAO ²
Author Information

1. Department of Hematology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China.
2. Department of Hematology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China. E-mail:ydsygao@sina.com.
Publication Type:Journal Article
From: Journal of Experimental Hematology 2017;25(4):1053-1057
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo evaluate the correlation of single nucleotide polymorphisms (SNP) of Gemin 3(rs197412) in the miRNA biosynthesis with NHL cancer risk and overall prognosis.
METHODSmiR-SNP were genotyped using PCR-ligase detection reaction(LAR, LCR) in NHL group of 230 non-Hodgkin lymphoma (NHL) patients and in control group of 120 healthy persons. The survival curves were drawn using the Kaplan-Meier method, and comparisons between the curves were made using the log-rank test. Multivariate survival analysis was performed by using a Cox proportional hazards model.
RESULTSThe rs197412 genotype distribution difference was not statistically significant, in NHL and control group; the survival time of patients carrying the rs197412 TT genotype was significantly longer than that of the patients carrying the CC+CT genotype (P=0.007). In addition, rs197412 was independent from the survival of NHL patients by multivariate analysis (RR: 2.138,95% CI: 1.303-3.508, P<0.01).
CONCLUSIONThe single nucleotide polymorphisms of Gemin 3 (rs197412) in the miRNA processing are not related with NHL risk, but that may affect NHL survival.