Changes of insulin resistance and islet beta cells function in subjects with high-normal blood pressure.
- Author:
Ling-Ling XU
1
;
Hong-Ding XIANG
;
Li-Hong ZHANG
;
Wei CHEN
;
Jing-Hui FANG
Author Information
- Publication Type:Journal Article
- MeSH: Blood Pressure; Body Mass Index; Body Weight; Cholesterol; blood; Cholesterol, LDL; blood; Humans; Hypertension; physiopathology; Insulin Resistance; physiology; Triglycerides; blood; Waist Circumference
- From: Acta Academiae Medicinae Sinicae 2009;31(4):494-497
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the changes of insulin resistance and islet beta cells function in subjects with euglycemia and high-normal blood pressure.
METHODSTotal 423 subjects were divided into normal blood pressure group and high-normal blood pressure group. Body height, weight, waist and hip circumference, and biochemical data were measured. Homeostasis model assessment of insulin resistance (HOMA-IR), insulin sensitivity index (ISI)-composite, and first-phase (1 PH) Stumvoll index were calculated. Results Waist circumference, total cholesterol, triglyceride, low-density lipoprotein cholesterol, HOMA-IR were significantly higher and IPH Stumvoll index and ISI-composite were significantly lower in high-normal blood pressure group than in normal blood pressure group (P < 0.05). Systolic blood pressure (SBP) was positively correlated with HOMA-IR (r = 0.122) and negatively correlated with 1PH Stumvoll index (r = -0. 159) and ISI-composite (r = -0.131) (P < 0.05). SBP and triglyceride were independent factors for IPH Stumvoll index.
CONCLUSIONInsulin resistance and islet dysfunction may exist in subjects with high-normal blood pressure.
