FLT3 mutation in patients with acute lymphoblastic leukemia and its clinical significance.
- Author:
Xin ZHAO
1
;
Ke-Jing TANG
;
Zheng TIAN
;
Li-Ping CHEN
;
Ying-Chang MI
;
Jian-Xiang WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Child; Child, Preschool; Female; Humans; Male; Middle Aged; Mutation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; genetics; Young Adult; fms-Like Tyrosine Kinase 3; genetics
- From: Acta Academiae Medicinae Sinicae 2009;31(5):522-526
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate fms-like tyrosine kinase 3 (FLT3) mutation in patients with acute lymphoblastic leukemia (ALL) and its clinical significance.
METHODSFLT3 mutation-internal tandem duplication (FLT3-ITD) and FLT3 mutation in the tyrosine kinase domain (FLT3-TKD) were detected using polymerase chain reaction (PCR) in the genomic DNA of 61 ALL patients and 7 healthy volunteers (as reference group). The PCR products of these patients who were detected with FLT3-ITD or FLT3-TKD were sent for sequence analysis.
RESULTSIn all these 61 ALL patients, FLT3-ITDs were identified in 2 patients and FLT3-TKD were identified in one patient.
CONCLUSIONFLT3-ITD and FLT3-TKD exist in a small proportion of ALL patients.
