Efficacy of intraperitoneally injected epirubicin-loaded poly (d, l)-lactic acid microspheres alone or combined with free epirubicin in treating hepatocellular carcinoma in mice.
- Author:
Jian-Yin ZHOU
1
;
Xiao-Min WANG
;
Qi-Qing ZHANG
;
She-Fang YE
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Delayed-Action Preparations; Epirubicin; administration & dosage; therapeutic use; Infusions, Parenteral; Lactic Acid; Liver Neoplasms, Experimental; drug therapy; Male; Mice; Microspheres; Polyesters; Polymers
- From: Acta Academiae Medicinae Sinicae 2009;31(5):603-606
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the efficacy of intraperitoneally injected epirubicin (EPI)-loaded poly (d, l)-lactic acid (PLA) microspheres (MS) alone or combined with free epirubicin (FEPI) in treating hepatocellular carcinoma (HCC) in mice.
METHODSMice that were transplanted with H22 ascites HCC were randomized into seven groups, which were intraperitoneally injected with blank microspheres, normal saline, three different doses of microspheres (9, 18, and 36 mg/kg EPI) , FEPI (9 mg/kg) , and the combination (microspheres with EPI 4.5 mg/kg + FEPI 4.5 mg/kg). The survival time of all animals was recorded. The rates of increase in life span of all the treatment groups were calculated.
RESULTSEPI-PLA-MS significantly prolonged the survival time of HCC mice in a dose-dependent manner, with a maximal tolerated dose (MTD) of 18 - 36 mg/kg. The combination group had the highest average survival time, median survival time, and rate of increase in life span, which were (40.0 +/- 16.9) days, 33.5 days, and 222.58%, respectively.
CONCLUSIONEPI-PLA-MS combined with FEPI is highly effective in treating HCC in mice when intraperitoneally injected.
