Basic and clinical research on paraneoplastic pemphigus.
- Author:
Jing LI
1
;
Xue-Jun ZHU
Author Information
1. Department of Dermatology, Peking University First Hospital, Beijing 100034, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Paraneoplastic Syndromes;
Pemphigus
- From:
Acta Academiae Medicinae Sinicae
2009;31(5):654-658
- CountryChina
- Language:Chinese
-
Abstract:
Paraneoplastic pemphigus (PNP) is an autoimmune blistering skin disease associated with neoplasms. Clinically, it is characterized by severe mucosal erosions and various cutaneous lesions. Suprabasal acantholysis and cleft with scattered necrotic keratinocytes are the unique histopathological features of PNP. The pathogenic autoantibodies existed in PNP sera, and their production was correlated with the associated tumor. Early detection and resection of the tumor are essential for the treatment of the disease.
