Association between monoamine oxidase A gene and major depression in Chinese Han population.
- Author:
Jie-xu ZHANG
1
;
Yan-bo CHEN
;
Ke-rang ZHANG
;
Qi XU
;
Yan SHEN
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Asian Continental Ancestry Group; genetics; Case-Control Studies; China; Depressive Disorder, Major; genetics; Female; Genetic Predisposition to Disease; Humans; Male; Minisatellite Repeats; genetics; Monoamine Oxidase; genetics; Polymorphism, Genetic; Promoter Regions, Genetic; genetics; Young Adult
- From: Acta Academiae Medicinae Sinicae 2009;31(6):728-734
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the association between monoamine oxidase A (MAOA) variable number tandem repeat (VNTR) polymorphism and major depression in Chinese Han population.
METHODSPolymerase chain reaction was used to genotype MAOA VNTR polymorphism. A total of 512 major depression patients and 566 normal controls were recruited in our study. These patients were also assessed using the 14-item Hamilton anxiety scale. RESULTS The allele frequency of MAOA VNTR was not significantly different between the male/female major depression patients and the normal controls. Compared with the normal controls, MAOA VNTR genotype was significantly more frequent in female major depression patients (P=0.002), but not in male patients (P=0.17). MAOA VNTR-L carrier was also associated with "fear" symptom in female patients (P=0.0056).
CONCLUSIONMAOA gene is associated with the major depression in Chinese Han population, especially among female patients.
