Current situation researching of methylation in tumor.
10.3881/j.issn.1000-503X.2009.06.028
- Author:
Di SHAO
1
;
An-fang CUI
;
Liu-luan ZHU
;
Ai-jun QIAO
;
Xing-xing KONG
;
Xiao-jun LIU
;
Yong-sheng CHANG
;
Fu-de FANG
Author Information
1. National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Beijing 100005, China.
- Publication Type:Journal Article
- MeSH:
DNA Methylation;
Histones;
metabolism;
Humans;
Methylation;
Neoplasms;
genetics;
metabolism
- From:
Acta Academiae Medicinae Sinicae
2009;31(6):786-790
- CountryChina
- Language:Chinese
-
Abstract:
The disorders of DNA and histone methylation have a close relationship with the development and progression of tumors. Epigenetic regulation is critical in maintaining the stability and integrity of the expression profiles of different cell types by modifying DNA methylation and histone methylation. However, the abnormal changes of methylation often result in the development and progression of tumors. This review summarized the theory of tumor genomic and histone methylation, detection methods of methylation and their applications, and the clinical application of methylation as biological markers and drug targets.
