Utilization of targeting specific proteins for ubiquitination and degradation.
10.3881/j.issn.1000-503X.2010.01.029
- Author:
Yi-hui MA
1
;
Qiang ZHANG
;
Jie CHEN
Author Information
1. Department of Pathology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Humans;
Proteasome Endopeptidase Complex;
metabolism;
Protein Binding;
Protein Transport;
Recombinant Proteins;
metabolism;
Ubiquitin-Protein Ligases;
metabolism;
Ubiquitination
- From:
Acta Academiae Medicinae Sinicae
2010;32(1):123-127
- CountryChina
- Language:Chinese
-
Abstract:
Ubiquitin-proteasome pathway (UPP) can degrade specific proteins in eukaryotic cells. Targeting specific proteins for ubiquitination and degradation technique, based the theory of UPP and using certain chimeric E3s or protein-targeting chimeric molecules, can specifically knock down the targeted proteins. It is a promising new method for exploring the functions of genes or proteins and, together with gene-silencing technique, may play an important role in basic and clinical research.
