The protective effect of melatonin on auditory cortex toxicity induced by cis-platinum.
- Author:
Ming-De HUANG
1
;
Xia SUN
;
Xi CAO
;
Qiong-Yao HU
;
Meng-Hui ZHAO
;
Yan-Qin YU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Auditory Cortex; drug effects; metabolism; pathology; Cisplatin; antagonists & inhibitors; toxicity; Female; Free Radical Scavengers; pharmacology; Guinea Pigs; Male; Malondialdehyde; metabolism; Melatonin; pharmacology; Neurons; drug effects; pathology; Random Allocation
- From: Chinese Journal of Applied Physiology 2009;25(4):539-542
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo investigate the toxic response in auditory cortex of guinea pigs caused by cis-platinum (DDP), and the protective role of melatonin in this effect.
METHODSCis-platinum and melatonin were injected peritoneally. LDH, MDA, NO in the auditory cortex were detected by spectrophotometeR.
RESULTSThe body weight of the guinea pigs was diminished by peritoneal injection of Cis-platinum for 7 days (P < 0.01). Peritoneal injection of Cis-platinum induced the increased leakage of LDH (P < 0.05 vs injection of normal saline). This effect was reduced by injection of MT (P < 0.05). The content of MDA in the auditory cortex was also increased because of injection of Cis-platinumv for 7 days (P < 0.01) and MT reduced this effect (P < 0.05). The change of NO in the auditory cortex was not statistically significant after injection of Cis-platinum or Cis-platinum with MT.
CONCLUSIONPeritoneal injection of Cis-platinum could destroy neurons in the auditory cortex. This effect could be reduced by melatonin by an anti-free radials mechanism.
