Experimental research of prevention and therapy effect of anisodamine on acute respiratory distress syndrome (ARDS).
- Author:
You-Ling JING
1
;
Yan-Lei WANG
;
Ying SUN
;
Chun-Xiu ZHAO
;
Hong-Jie LI
;
Xiao-Yan KONG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Disease Models, Animal; Female; Free Radical Scavengers; therapeutic use; Lipid Peroxidation; drug effects; Male; Oleic Acid; Rabbits; Random Allocation; Respiratory Distress Syndrome, Adult; chemically induced; drug therapy; prevention & control; Solanaceous Alkaloids; therapeutic use
- From: Chinese Journal of Applied Physiology 2009;25(4):557-560
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo study preventive and therapeutic effect of anisodamine on acute respiratory distress syndrome(ARDS) induced by oleic acid and their mechanism of action.
METHODSModel of ARDS was made in rabbits by oleic acid (OA). The effect of anisodamine on the malondialdehyde (MDA), fibronectin (FN), lactate dehydrogenase (LDH) and acid phosphatase (ACP) in plasma, and superoxide dismutase (SOD) in erythrocyte and MDA, SOD and pulmonary surfactant (PS) in lung tissues homogenate and pathological examination of lung were observed.
RESULTSThe administration of anisodamine before and after 30 minutes of injection OA decreased MDA, LDH and ACP, prevented the reduction of SOD, FN and PS. Compared with ARDS group, there was marked difference between the two, and alleviated lung injury.
CONCLUSIONAnisodamine possesses preventive and therapeutic effects on ARDS by inhibiting lipid peroxidation and stabilizing membranes.
