Studies on polysomnogram of the post-stroke depression in rat.
- Author:
Xu-Sheng WANG
1
;
Jing-Gui SONG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Depressive Disorder; etiology; physiopathology; Disease Models, Animal; Male; Polysomnography; Rats; Rats, Sprague-Dawley; Stroke; complications
- From: Chinese Journal of Applied Physiology 2010;26(4):510-512
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore detection method on polysomnogram of post-stroke depression and changes in rats.
METHODSMale Sprague-Dawley rats were randomly assigned to control group, stroke group, and post-stroke depression (PSD) group. The establishment of PSD model generally adopted the combination of deligation bilateral common carotid artery permanently raising alone and stress exertion. And suturing electrode under the rat scalp for polysomnogram.
RESULTSThe polysomnogram could record the rats movement, electroencephalogram, electromyogram, and eye movement. The rapid eye movement (REM) latency of PSD group, and control group, stroke group were (108.2 +/- 16.1)s, (152.5 +/- 20.5)s, (145.1 +/- 18.7)s respectively. Compared with control, and stroke group, REM latency in PSD group were shortened (P < 0.01). The percentage of REM in PSD group, control group and stroke group were 5.2% +/- 1.2%, 8.3% +/- 1.4%, 7.9% +/- 1.6% respectively. Compared with control, and stroke group, REM latency in PSD group was decreased (P < 0.01).
CONCLUSIONThe method of suturing electrode under the rat scalp is suitable for polysomnogram. The polysomnogram could be a successful sign for PSD model.
