Intratympanic versus systemic steroid treatment for idiopathic sudden hearing Ioss:a Meta-analysis
10.3760/cma.j.issn.1673-0860.2013.05.012
- VernacularTitle:鼓室内与全身应用糖皮质激素治疗突发性聋的Meta分析
- Author:
Xiu-Yong DING
1
;
Ting-Ting CUI
;
Guo-Dong FENG
;
Zhi-Qiang GAO
Author Information
1. 100730,中国医学科学院北京协和医学院北京协和医院耳鼻咽喉科
- Keywords:
Hearing loss,sudden;
Glucocorticoids;
Drug administration routes;
Meta-analysis
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2013;48(5):412-416
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the effectiveness and safety of intratympanic versus systemic steroid therapy in the initial treatment of idiopathic sudden hearing loss.Methods An extensive search of the literature was performed in Pubmed and other available database from January,1980 to November,2011.After filtering by the criteria of Cochrane Collaboration,a meta-analysis was conducted.Results Nine studies met the criteria for meta-analysis,for idiopathic sudden hearing loss patients without diabetes received intratympanic steroid therapy,the improvement rate (RR =1.11,95％ CI =0.96-1.28,P =0.15) did not show any significance when compared with the patients received systemic therapy.While a significant difference of improvement rate occurred between intratympanic and systemic steroid therapy in the idiopathic sudden hearing loss patients with diabetes (RR =1.24,95％ CI =1.02-1.50,P =O.03).Conclusion For the initial therapy of idiopathic sudden hearing loss patients without diabetes,systemic steroid treatment still remains the first choice,but for the idiopathic sudden hearing loss patients with diabetes,intratympanic steroid treatment should be used for the initial treatment.
