Efficacy of sublingual immunotherapy with Dermatophagoides farinae drops in monosensitized and polysensitized patients with allergic rhinitis
10.3760/cma.j.issn.1673-0860.2013.07.006
- VernacularTitle:舌下含服粉尘螨滴剂治疗单一和多重过敏变应性鼻炎患者的临床疗效评估
- Author:
Bo-Ya CHEN
1
;
Zi-Ming LONG
;
Yan-Jun HUANG
;
Jian-Ming ZENG
Author Information
1. 523710,广东省东莞三局医院耳鼻咽喉科
- Keywords:
Rhinitis,allergic,perennial;
Desensitization,immunologic;
Administration,sublingual;
Allergens;
Treatment outcome
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2013;48(7):549-554
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the efficacy of sublingual immunotherapy (SLIT) with standardized Dermatophagoides farinae drops in monosensitized and polysensitized patients with allergic rhinitis.Methods The efficacy of SLIT in 69 patients who were sensitized to house dust mites and treated with Dermatophagoides farinae drops for 1.5-2.0 year with complete clinical data were analyzed retrospectively.These patients had been divided into the monoallergen sensitized group and polyallergen sensitized group according to the results of skin prick tests.The total medication score (TMS) and the total nasal symptoms score (TNSS) were evaluated before and half an year,1.0 year and 1.5-2.0 years after SLIT treatment.Results After SLIT treatment for half an year,the TNSS in the monoallergen sensitized group (2.00 [1.00; 3.00]) was significantly lower than that in the polyallergen sensitized group (3.00 [2.00 ;4.00],Z =-2.851,P ＜ 0.05),this significant difference of TNSS between the two groups was also found after SLIT treatment for 1.0 year (0.00 [0.00 ; 1.00],2.00 [0.00 ; 3.00],Z =-2.590,P ＜0.05).Whereas,there was no significant difference between the two groups after 1.5-2.0 years'treatment refer to the TNSS (0.00 [0.00 ; 1.00],0.00 [0.00 ; 2.00],Z =-1.461,P ＞ 0.05).Half an year,1.0 year and 1.5-2.0 years after SLIT treatment,the TMS in both groups reduced significantly,with no significant difference between two groups (Z value was-0.777,-0.944,-0.907,all P ＞ 0.05).Conclusions SLIT with Dermatophagoides farinae drops is effective in monosensitized and polysensitized patients with allergic rhinitis.And equivalent efficacy could be achieved after 1.5-2.0 years.
