Tea Polyphenols Exerts Anti-hepatitis B Virus Effects in a Stably HBV-transfected Cell Line
10.1007/s11596-009-0206-1
- Author:
YE PIAN
1
;
ZHANG SHULING
;
ZHAO LEI
;
DONG JIHUA
;
JIE SHENGHUA
;
PANG RAN
;
LI SHULI
Author Information
1. Department of Hepatology and Infectious Diseases,Union Hospital,Tonal Medical College,Huazhong University of Science and Technology,Wuhan 430022,China
- Keywords:
liver diseases;
hepatitis B virus;
anti-HBV effect;
tea polyphenols (TP);
HepG2 2.2.15
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2009;29(2):169-172
- CountryChina
- Language:Chinese
-
Abstract:
In this study,the anti-HBV effects of tea polyphenols (TP) were examined.After cells were exposed to TP for 3,6,9 days,amounts of HBsAg,HBeAg and HBV-DNA released into the supernatant of the cultured HepG2 2.2.15 cells were detected.TP,to some extent,inhibited the secre-tion of HBsAg and strongly suppressed the secretion of HBeAg in a dose-dependent (P<0.01) and time-dependent manner,with 50% maximal inhibitory concentration (IC50) value being 7.34 μg/mL on the 9th day,but the time-dependence was not significant (P=0.051).Expression of HBV-DNA in the supernatant of the cell culture also was significantly decreased in a dose-dependent fashion (P<0.01).The IC50 of TP in inhibiting HBV DNA was 2.54 μg/mL.It concluded that TP possessed potential anti-HBV effects and may be used as a treatment alternative for HBV infection.
