Expression of Phosphorylated-STAT3 and Osteopontin and Their Correlation in Melanoma
10.1007/s11596-009-0223-0
- Author:
WU YAN
1
;
JIANG PING
;
LIN YUN
;
CHEN SIYUAN
;
LIN NENGXING
;
LI JIAWEN
Author Information
1. Department of Dermatology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China
- Keywords:
p-STAT3;
osteopontin;
malignant melanoma;
invasion;
metastasis;
tumor thickness
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2009;29(2):246-250
- CountryChina
- Language:Chinese
-
Abstract:
The expressions of p-STAT3 and osteopontin in 22 cases of normal nevi and 43 cases of malignant melanoma were immunohistochemically detected,and the correlation between p-STAT3 and osteopontin in malignant melanoma and the correlations of p-STAT3 (or osteopontin) with invasion,metastasis and thickness of malignant melanoma were examined.The results showed p-STAT3 was expressed in 2 of 22 cases of normal nevi and 30 of 43 cases of malignant melanoma,while osteopontin was expressed in 3 cases of normal nevi and 29 cases of malignant melanoma.The expressions of p-STAT3 and osteopontin in melanoma were significantly higher than that in benign nevi.There existed significant correlations between the expression of p-STAT3 and that of osteopontin in melanoma.Furthermore,the expression rates of p-STAT3 were significantly higher in invasive or metastatic melanomas than that their non-invasive or non-metastatic counterparts,and the expression rates of osteopontin were significantly higher in invasive melanomas than that in non-invasive ones.It is concluded that p-STAT3 and osteopontin may play important roles in the pathogenesis of malignant melanoma.
