Alcohol Drinking, Cigarette Smoking and Risk of Colorectal Cancer in the Korean Multi-center Cancer Cohort.
10.15430/JCP.2015.20.2.147
- Author:
Sooyoung CHO
1
;
Aesun SHIN
;
Sue K PARK
;
Hai Rim SHIN
;
Soung Hoon CHANG
;
Keun Young YOO
Author Information
1. Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea. shinaesun@snu.ac.kr
- Publication Type:Multicenter Study ; Original Article
- Keywords:
Colorectal neoplasms;
Smoking;
Alcohol drinking;
Prospective studies
- MeSH:
Adult;
Alcohol Drinking*;
Cohort Studies*;
Colorectal Neoplasms*;
Female;
Follow-Up Studies;
Humans;
Male;
Proportional Hazards Models;
Prospective Studies;
Smoking*;
Tobacco Products*
- From:Journal of Cancer Prevention
2015;20(2):147-152
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The present study aimed to examine the association between cigarette smoking, alcohol consumption and colorectal cancer risk among Korean adults. METHODS: Data from the Korean Multi-center Cancer Cohort between 1993 and 2005 were analyzed. The study population comprised 18,707 subjects aged older than 20 years old. The subjects were followed until December 31, 2011 (median follow-up of 11.2 years). The Cox proportional hazard model was used to estimate the hazard ratio (HR) and 95% confidence intervals of cigarette smoking and alcohol consumption for colorectal cancer risk. RESULTS: In men, longer duration and higher average amount of alcohol consumption were associated with elevated risk of colorectal cancer (HR 1.93 [1.17-3.18] for > or = 30 years of consumption compared to non-drinkers; HR 2.24 [1.31-3.84] for > or = 30 g/d). Former smokers showed a non-significantly elevated risk of colorectal cancer in men. There was no apparent association between alcohol consumption or cigarette smoking and colorectal cancer risk among women. CONCLUSIONS: Alcohol consumption was associated with increased colorectal cancer risk among Korean men, and both a longer duration and a higher amount of consumption were associated with elevated risk.
