Simvastatin Increases the Activity of Endothelial Nitric Oxide Synthase via Enhancing Phosphorylation
10.1007/s11596-009-0304-0
- Author:
LI XIAOXIA
1
;
WANG PEIHUA
;
XU XIZHEN
;
WANG YONG
;
XIA YONG
;
WANG DAOWEN
Author Information
1. The Institute of Hypertension and Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science, Wuhan 430030, China
- Keywords:
simvastatin;
nitric oxide synthase;
phosphorylation;
endothelial cells
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2009;29(3):286-290
- CountryChina
- Language:Chinese
-
Abstract:
. These results suggest that simvastatin could stimulate the activity of eNOS via its phosphorylation by Akt and AMPK, which provides a new mechanism, other than lipid-lowering effect, for the cardiovascular protection of statins.
