The Effects of PDTC on Interleukin-1β-induced Nitric Oxide Production in Chondrocytes
10.1007/s11596-009-0307-x
- Author:
LIU JIANXIANG
1
;
DU JINGYUAN
;
YANG SHUHUA
;
QIU XIAOHUA
;
LIU RIGUANG
;
YI CHENGQING
;
LI XINCHUN
Author Information
1. Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022,China
- Keywords:
pyrrolidine dithiocarbamate;
chondrocyte;
nitric oxide;
nuclear factor-kappa B
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2009;29(3):300-303
- CountryChina
- Language:Chinese
-
Abstract:
S and NO production induced by rhIL-1β in a concentration-dependent manner. It is suggested that PDTC can inhibit NO production and iNOS mRNA expression induced by IL-1β, which may provide an alternative method for the treatment of osteoarthritis.
