The Neuroprotective Effects of Cyclin-dependent Kinase-5 Inhibition in Mice with Niemann-Pick Disease Type C
10.1007/s11596-009-0312-0
- Author:
HAO YOUGUO
1
;
PAN DENGJI
;
ZHANG MIN
;
XU JINZHI
;
LI LINJUAN
;
WEI JIAJUN
;
WANG XUEZHEN
Author Information
1. Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan Wuhan 430030, China
- Keywords:
Niemalm-Pick disease type C;
cyclin dependent kinase-5;
cytoskeleton hyperphos-phorylation;
small interfering RNA;
recombinant adeno-associated virus
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2009;29(3):324-329
- CountryChina
- Language:Chinese
-
Abstract:
significantly attenuated the hyper-phosphorylation of tau proteins. These data suggested that inhibition of cdk-5 activity has neuropro-tective effect on neurons in NPC mice.
