Total and Dietary Calcium Intake and Colorectal Adenoma in Korean Adults.
10.15430/JCP.2015.20.2.153
- Author:
Ju Eun SEOL
1
;
Chang Ho CHO
;
Sung Hi KIM
;
Jung Eun LEE
Author Information
1. Department of Food and Nutrition, College of Human Ecology, Sookmyung Women's University, Seoul, Korea. junglee@sm.ac.kr
- Publication Type:Original Article
- Keywords:
Calcium;
Colorectal neoplasms
- MeSH:
Academic Medical Centers;
Adenoma*;
Adult*;
Calcium;
Calcium, Dietary*;
Colonoscopy;
Colorectal Neoplasms;
Cross-Sectional Studies;
Daegu;
Diet;
Female;
Humans;
Korea;
Logistic Models;
Male;
Odds Ratio;
Prevalence
- From:Journal of Cancer Prevention
2015;20(2):153-158
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Colorectal cancer in Korea has become more prevalent over the few last decades, and calcium is considered a preventive factor for colorectal cancer development. We examined the associations between total and dietary calcium intake and the prevalence of colorectal adenoma in Korean adults. METHODS: This cross-sectional study included 112 colorectal adenoma cases and 252 adenoma-free non-cases, aged 45 to 71 years, who underwent colonoscopies at the Daegu Catholic University Medical Center from August 2011 to September 2012. Participants were asked about their diet using a validated food frequency questionnaire and about supplement use through interviews. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) to evaluate the association between total and dietary calcium intake and the prevalence of colorectal adenomas using multivariable logistic regression models. RESULTS: Increasing total calcium intake from foods and supplements was significantly associated with a decreased prevalence of colorectal adenoma in women; comparing the highest quartile with the lowest quartile, the OR (95% CI) was 0.35 (0.15-0.85; P for trend = 0.03). Likewise, high dietary calcium intake from foods was associated with a lower prevalence of colorectal adenoma in women; compared with the lowest quartile, the ORs (95% CIs) were 0.32 (0.13-0.82) for the 3rd quartile and 0.44 (0.19-1.03; P for trend = 0.13) for the 4th quartile. However, the association was not clear for either total or dietary calcium intake among men. CONCLUSIONS: A higher intake of calcium was associated with a reduction of colorectal adenoma prevalence in Korean women.
