Wortmannin Inhibits K562 Lukemic Cells by Regulating PI3k/Akt Channel In Vitro
10.1007/s11596-009-0412-x
- Author:
WU QING
1
;
CHEN YAN
;
CUI GUOHUI
;
CHENG YIQUAN
Author Information
1. Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022 China
- Keywords:
wortmannin;
K562 cell;
p-AKT;
NF-κB;
IKK-κB
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2009;29(4):451-456
- CountryChina
- Language:Chinese
-
Abstract:
ssion of total Akt showed no change. It is concluded that wortmannin can inhibit the proliferation and induce apoptosis of K562 leukemia cells possibly by down-regulating the survival signaling pathways (PI3K/Akt and NF-κB channels).
