Chelation of GRP78 with Lead and Its Localization Changes in the Astroglia of Rats Exposed to Lead

Author: ZHANG YING ¹ ; YE LIPING ; WANG BIAO ; LI YAN ; SUN LIGUANG
Author Information

1. Institute of Neurology, China Medical University, Shenyang 110001, China
Keywords: lead; astroglia; GRP78; chelation
From: Journal of Huazhong University of Science and Technology (Medical Sciences) 2009;29(4):492-497
CountryChina
Language:Chinese
Abstract: remarkably increase when it transferred from ER to the cytosol around the nuclei 24 h after treatment with Pb. It is concluded that GRP78 in astroglia could strongly chelate with Pb ions and it might be a target protein of Pb.