Multivariate analysis of the efficacy of laparoscopic splenectomy in the treatment of immune thrombocytopenic purpura.
- Author:
Jun-wei HUANG
1
;
Xiong YAN
2
;
Jun ZHENG
;
Xian-bing KONG
;
Shi-qiao LUO
;
Hong-bin ZHANG
;
Xiao-qiong TANG
;
Li WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Female; Humans; Laparoscopy; Male; Middle Aged; Multivariate Analysis; Purpura, Thrombocytopenic, Idiopathic; surgery; Retrospective Studies; Splenectomy; Treatment Outcome; Young Adult
- From: Chinese Journal of Surgery 2013;51(10):879-881
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo identify factors that can effectively predict the efficacy of laparoscopic splenectomy (LS) in the treatment of immune thrombocytopenic purpura (ITP).
METHODSFrom January 2007 to September 2012, 78 patients with ITP underwent laparoscopic splenectomy were retrospectively analyzed. According to the postoperative platelet (PLT) count and haemorrhagic manifestations, they were divided into effective group and ineffective group. Nine influencing factors were univariate analyzed and multivariate analyzed.
RESULTSIn effective group (65 cases) and ineffective group (13 cases), average PLT count of 1 day before surgery was 47×10(9)/L vs. 21×10(9)/L, average operative time was (166 ± 46) minutes vs. (139 ± 29) minutes. Univariate analysis result: PLT count of 1 day before surgery (Z = -2.776, P = 0.005) and operative time (t = 2.723, P = 0.011) was statistically significant in 2 groups, the rest factors did not significantly influence the result. Multivariate analysis revealed that only PLT count of 1 day before surgery was statistically significant (OR = 0.964, 95%CI: 0.932-0.997, P = 0.031) in 2 groups, but operative time (P = 0.051) was not statistically significant.
CONCLUSIONSPLT count of 1 day before surgery is a predict factor in LS for ITP. Because of the limited sample number, further multi-center prospective study with large sample is warrant.
